It can be shown by molecular model building and semi-empirical calculation that a complex of four nucleotides (C4N) composed of three anticodonic bases and a discriminator base can discriminate its cognate amino acid by the lock and key relationship. Possible evidence for the detection of such complexes (the C4N and theC4N-amino acid complexes) are presented by using fast atom bombardment-mass spectroscopy.
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Mikio Shimizu (1987) studied this question.
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