Doing the rounds: A highly straightforward approach has been developed that provides access to DNA minicircles containing a 21-mer single-stranded gap region of defined sequence (see picture). The single-stranded domain within a small circular DNA nanoobject provides the exciting opportunity to further functionalize a minicircle at defined positions in almost unlimited fashion, simply by hybridization with a synthetic 21-mer oligonucleotide.
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Rasched et al. (2007) studied this question.
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