Linking rings: A general route toward the clerodane diterpene core using an asymmetric Morita-Baylis-Hillman (MBH)/Lewis acid mediated ring-annulation process has been developed. The scope of the asymmetric Brønsted acid catalyzed MBH reaction has been expanded to include silane-containing aldehydes, which are elaborated into the trans decalin core in high diastereo- and enantioselectivities.
No takes yet. Share an insight, caveat, or question.
Rodgen et al. (2006) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: