The synthesis of enantiopure A-factor [‘autoregulatory factor’; (3R)-(–)-2-(6-methylheptanoyl)-3-hydroxymethylbutano-4-lactone] by the completely diastereoselective benzyloxymethylation of (4R)-3-(3-phenylpropanoyl)-4-isopropyloxazolidin-2-one is reported.
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Crawforth et al. (1998) studied this question.
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