Rheumatoid Arthritis: Ultrastructure of the Synovium

Editorial Notes1 March 1967Rheumatoid Arthritis: Ultrastructure of the SynoviumPHILIP M. GRIMLEY, M.D.PHILIP M. GRIMLEY, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-66-3-623 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptSeveral lines of investigation have recently focused attention on the ultrastructure of the synovium in rheumatoid arthritis. Electron microscopy has shown that a significant proportion of the synovial lining cells correspond to macrophages in both cytologic organization and phagocytic potential (1, 2). These cells, sometimes designated type A or type M, undergo a pronounced hyperplasia in rheumatoid arthritis and display intense acid phosphatase activity. Multinucleated giant cells of macrophage (type A cell) origin also occur with some frequency (3) and contain similar hydrolytic enzyme.Current thinking about the nature of rheumatoid arthritis is dominated by a concern with hypersensitivity mechanisms,...References1. MUIRDEN KD: Ferritin in synovial cells in patients with rheumatoid arthritis. Ann. Rheum. Dis. 25: 387, 1966. CrossrefMedlineGoogle Scholar2. NORTONZIFF WLM: Electron microscopic observations on the rheumatoid synovial membrane. Arthritis Rheum. 9: 589, 1966. CrossrefGoogle Scholar3. GRIMLEYSOKOLOFF PML: Synovial giant cells in rheumatoid arthritis. Amer. J. Path. 49: 931, 1966. MedlineGoogle Scholar4. HOLLANDERFUDENBERGRAWSONABELSONTORRALBA JLHHAJNMTP: Further studies on the pathogenesis of rheumatoid joint inflammation. Arthritis Rheum. 9: 675, 1966. CrossrefMedlineGoogle Scholar5. ZUCKER-FRANKLIN D: The phagosomes in rheumatoid synovial fluid leukocytes. A light, fluorescence, and electron microscopic study. Ibid., p. 24. Google Scholar6. CHAPMANTAYLOR JRG: Immuno-electron microscopy of selected cells in tissue sections. J. Roy. Micr. Soc. 85: 455, 1966. CrossrefGoogle Scholar7. HIGHTONCAUGHEYRAYNS TCDEDG: A new inclusion body in rheumatoid synovia. Ann. Rheum. Dis. 25: 149, 1966. CrossrefMedlineGoogle Scholar8. ROSSGREENLEE RTK: Electron microscopy: attachment sites between connective tissue cells. Science 153: 997, 1966. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Pathologic Anatomy Branch General Laboratories and Clinics National Cancer Institute Bethesda, Md. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byGeneral Pathology of the Peripheral JointsStructure of Synovial Membrane in Rheumatoid ArthritisBeitrag zur Kenntnis der juvenilen monartikul�ren rheumatoiden ArthritisNineteenth rheumatism review. Part-IIIRecent Advances in Rheumatic Diseases: 1967 Through 1969RICHARD H. FERGUSON, M.D., F.A.C.P., JOHN W. WORTHINGTON, M.D., F.A.C.P.The microvasculature of the synovial membrane of the monkey: Ultrastructural studiesThe synovitis of pseudogout: electron microscopic observations 1 March 1967Volume 66, Issue 3Page: 623-624KeywordsAcid phosphataseCellsElectron microscopyEnzymesGiant cellsHypersensitivityRheumatoid arthritis Issue Published: 1 March 1967 PDF downloadLoading ...