Key result
Far infrared radiation reduced hepatic lipid deposition, liver injury, and inflammation in a methionine choline-deficient diet-induced NAFLD mouse model by activating AMPK.
Why the study?
The mechanisms underlying non-alcoholic fatty liver disease are not fully understood and specific drug therapies are lacking, while far infrared radiation has shown therapeutic efficacy across various diseases.
Does far infrared radiation ameliorate non-alcoholic fatty liver disease in mice?
Does far infrared radiation ameliorate non-alcoholic fatty liver disease in mice?
Far infrared radiation shows potential as a novel therapeutic approach for NAFLD by reducing hepatic lipid deposition and inflammation via AMPK activation in a mouse model.
Background & Aims:Non-alcoholic fatty liver disease (NAFLD) is a disease that causes an abnormal accumulation of fat in the liver, triggering inflammation and liver damage, the mechanism of which is not fully understood and for which there is a lack of specific drug therapy. Far infrared radiation (FIR) has demonstrated evident therapeutic efficacy across various diseases, and it can be emitted by novel nanomaterial graphene patches through electric heating. This study aimed to investigate the potential protective effects of FIR against NAFLD. Methods: Mice were fed with MCD diet to mimic NAFLD progression, and the effect of FIR on NAFLD was assessed by histopathology analysis, biochemical analysis, RT-qPCR, and Western blotting analysis. The effect of FIR treatment on lipid deposition in hepatocytes was investigated by cell culture in vitro. Results: Mice subjected to MCD diet and treated with FIR exhibited reduced hepatic lipid deposition, liver damage and inflammation. The therapeutic effect exerted by FIR in mice is most likely attributed to the enhancement of AMPK phosphorylation. Besides, FIR intervention alleviated lipid accumulation in hepatocytes in vitro. Conclusion: Our results revealed a promising potential of FIR as a novel therapeutic approach for NAFLD.
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xu et al. (2023) studied Non-alcoholic fatty liver disease (NAFLD). Far infrared radiation (FIR) vs. MCD diet without FIR was evaluated on Hepatic lipid deposition and inflammation. Far infrared radiation reduced hepatic lipid deposition, liver injury, and inflammation in a methionine choline-deficient diet-induced NAFLD mouse model by activating AMPK.
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