Differentiation of enantiotopic groups is an alternative in stereoselective synthesis to the standard way of differentiating enantiotopic faces. Chiral Grignard reagents are able to differentiate the enantiotopic iodine atoms of 1,1-diiodoalkanes and lead to enantiomerically enriched configurationally stable α-iodoalkylmagnesium reagents [Eq. (1)].
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Schulze et al. (1999) studied this question.