E-mail: eslee@yu.ac.kr Received December 5, 2011, Accepted February 9, 2012Key Words : Terpyridine, 2,4-Diaryl-5,6-dihydro-1,10-phenanthroline, Topoisomerase I and II, CytotoxicityWith a goal to discover new anticancer agents, our researchgroup studied various terpyridine derivatives for their topo-isomerase (topo) I and II inhibitory activity, and cytotoxicity.Previously, only flexible derivatives were studied for theanticancer activity.
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