Key result
Phospholipase A2 inhibitors and cyclooxygenase inhibitors inhibited carrageenan and thrombin-induced aggregation of rabbit platelets independent of prostaglandin synthetase-derived products.
Population
plasma-free rabbit platelets
Design
Preclinical
Authors
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Suggests non-prostaglandin PLA2 pathways in rabbit platelet aggregation; leaves open relevance to human antiplatelet strategies.
Carrageenan and thrombin-induced platelet aggregation in rabbits appears to be mediated by non-prostaglandin, phospholipase A2-derived products.
B. Boris Vargaftig (1977) studied this question. Phospholipase A2 inhibitors and cyclooxygenase inhibitors was evaluated on Platelet aggregation and prostaglandin-like activity formation. Phospholipase A2 inhibitors and cyclooxygenase inhibitors inhibited carrageenan and thrombin-induced aggregation of rabbit platelets independent of prostaglandin synthetase-derived products.
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