Key result
This review describes and evaluates experimental evidence linking behavioral recovery following vestibular damage to the body's adaptive stress response via the hypothalamic-pituitary-adrenal axis.
This review explores the experimental evidence linking vestibular compensation following unilateral vestibular deafferentation to the body's adaptive stress response via the HPA axis.
Should not yet change vestibular rehabilitation; leaves open HPA-axis modulation as a therapeutic target pending clinical trials.
Vestibular compensation is defined as the process of behavioural recovery that occurs following the loss of sensory input from one or both vestibular labyrinths. The visual and postural instability resulting from the vestibular damage must alter the homeostasis of the subject; however, very little research has been conducted that investigates the interaction between vestibular compensation and the adaptive stress response of the body, i.e. the hypothalamic-pituitary-adrenal (HPA) axis. The aim of this review is to describe and evaluate the experimental evidence indicating a link between vestibular compensation and the body's response to stress, via the HPA axis.
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Gliddon et al. (2003) conducted a review in Unilateral Vestibular Deafferentation. Vestibular compensation and HPA axis interaction was evaluated. This review describes and evaluates experimental evidence linking behavioral recovery following vestibular damage to the body's adaptive stress response via the hypothalamic-pituitary-adrenal axis.
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