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When the anticholinergic drug ipratropium bromide is given as a nasal spray, it can reach the glandular cholinoceptors and block the secretory response to methacholine. Nine placebo-controlled clinical trials have shown that the treatment significantly reduces watery rhinorrhea in patients with perennial rhinitis not responsive to other types of treatment. To avoid a sensation of nasal dryness as a side effect from spraying, it is important in the individual patient to match the dosage to the severity of hypersecretion. Ipratropium has no effect on sneezing or on nasal blockage.
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Mygind et al. (1990) studied this question.
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