Key result
In human umbilical vein endothelial cells, SERCA plays a powerful and dynamic role in regulating cytosolic free Ca2+ oscillations, modulating the phases of Ca2+ release and the falling phase.
SERCA plays a powerful and dynamic role in regulating cytosolic free Ca2+ oscillations in human umbilical vein endothelial cells, modulating both the upstroke and downstroke of Ca2+ spikes.
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Supports SERCA modulation of endothelial Ca2+ oscillations; hypothesis-generating and leaves open clinical translation.
Morgan et al. (1998) studied this question. Cyclopiazonic acid (CPA) was evaluated on Cytosolic free Ca2+ oscillations and spike phases. In human umbilical vein endothelial cells, SERCA plays a powerful and dynamic role in regulating cytosolic free Ca2+ oscillations, modulating the phases of Ca2+ release and the falling phase.
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