Key result
Atrial pacing-induced ischemia significantly decreased E-MAX in 8 of 10 patients (P<.05), which was attenuated by intravenous nitroglycerin except in the presence of coronary collaterals.
Why the study?
Does intravenous nitroglycerin improve ventricular contractility (E-MAX) during atrial pacing-induced ischemia in patients with presumed coronary artery disease?
Population
10 patients undergoing cardiac catheterization for presumed coronary artery disease
Comparison
Atrial pacing-induced ischemia followed by… vs Baseline measurements
Design
Case_series
Authors
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Should not yet alter nitroglycerin use in ischemia; leaves open collateral effects in larger studies.
Does intravenous nitroglycerin improve ventricular contractility (E-MAX) during atrial pacing-induced ischemia in patients with presumed coronary artery disease?
p-value: p=<.05
Intravenous nitroglycerin attenuates pacing-induced ischemic decreases in ventricular contractility, except in patients with well-developed coronary collaterals.
Spaccavento et al. (1990) studied presumed coronary artery disease (n=10). Atrial pacing-induced ischemia and intravenous nitroglycerin vs. baseline was evaluated on constant of elastance (E-MAX) (p=<.05). Atrial pacing-induced ischemia significantly decreased E-MAX in 8 of 10 patients (P<.05), which was attenuated by intravenous nitroglycerin except in the presence of coronary collaterals.
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