Why the study?
Despite physical exercise being a known therapeutic tool in managing renin-angiotensin system conditions, its effects on AT1R and AT2R receptor expression had not been systematically synthesized.
Does physical exercise alter the expression of angiotensin II receptors (AT1R and AT2R)?
Population
11 studies (10 in experimental animal models and 1 involving humans)
Comparison
Physical exercise vs control conditions or baseline
Design
Systematic review
Key result
Chronic cyclic physical exercise was associated with reduced AT1R expression and increased AT2R expression in various tissues, whereas resistance exercise increased AT1R expression.
Authors
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Exercise may favorably modulate RAS balance; extends preclinical insights but leaves clinical translation open.
Systematic Review (n=11)
Does physical exercise alter the expression of angiotensin II receptors (AT1R and AT2R)?
Chronic cyclic physical exercise may beneficially modulate the renin-angiotensin system by reducing AT1R and increasing AT2R expression, though current evidence is largely preclinical.
Oliveira et al. (2026) reported a systematic review. Physical exercise was evaluated on Expression of angiotensin II receptors (AT1R and AT2R). Chronic cyclic physical exercise was associated with reduced AT1R expression and increased AT2R expression in various tissues, whereas resistance exercise increased AT1R expression.