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September 2, 2026mSphereOpen Access

Aerosol-based disinfection protocol for aircraft: a solution for the conflict between material compatibility and antimicrobial efficacy

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Authors

SKSandro KlafackJKJessica KohsKSK. Schwenke

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Overview

Validation study demonstrates effective dry-fog decontamination without damaging materials in an Airbus A320, suggesting a viable airborne protocol against dangerous transmissible pathogens.

Key Points

  • To develop and validate an aerosol-based room disinfection method using peroxyacetic acid stabilized with hydrogen peroxide that balances antimicrobial efficacy with strict aircraft material safety requirements.
  • Determined minimal effective antimicrobial concentrations of aerosolized peroxyacetic acid (aPAA) against bacteria, viruses, and bacterial endospores.
  • Conducted European Union Aviation Safety Agency (EASA) material compatibility tests on a comprehensive panel of aircraft materials.
  • Validated the disinfection protocol inside an Airbus A320 aircraft cabin using challenge organisms, including bacteriophage MS2 and Geobacillus stearothermophilus spores.
  • The aPAA dry-fog protocol passed all required EASA material compatibility certification specifications without compromising aircraft airworthiness.
  • Full in-aircraft validation confirmed complete antimicrobial efficacy against the most resilient challenge organisms tested, specifically bacteriophage MS2 and G. stearothermophilus endospores.

Cite This Study

Klafack et al. (2026) studied this question.

synapsesocial.com/papers/6a97e25ec562ede874ec6833https://doi.org/10.1128/msphere.00542-26
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