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September 2, 2026Microbiology SpectrumOpen Access

Genomic architecture of antimicrobial resistance and mobile genetic elements in Salmonella enterica isolated from necropsied cattle in central Kentucky

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Authors

NFNada A. FahmyFKFayza KouadrıLBLogan Burns

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Overview

Genomic analysis reveals diverse resistance determinants and mobile elements in cattle Salmonella enterica, suggesting cross-compartment transmission within One Health networks.

Key Points

  • Characterize the genomic antimicrobial resistance, virulence, and mobile genetic element profiles of Salmonella enterica isolates recovered from necropsied cattle.
  • Sequenced and analyzed the whole genomes of 27 Salmonella enterica isolates recovered from necropsied cattle in central Kentucky.
  • Screened genomic sequences for multilocus sequence types (MLST), virulence determinants, antimicrobial resistance genes (ARGs), and mobile elements including plasmids, integrons, prophages, and insertion sequences (IS).
  • Performed pan-genome characterization and core-genome phylogenetic analysis incorporating 97 publicly available Salmonella genomes from human, food, and environmental reservoirs.
  • Identified 12 sequence types with ST10 (S. Dublin) predominant at 25.9%, detecting 4,618 virulence gene occurrences and frequent efflux-associated resistance genes (62.1%).
  • Observed plasmids in 77.8% and integrons in 11.1% of isolates, with 63.5% of resistance loci located on chromosomes and 11.7% on plasmids near mobile insertion sequence elements.
  • Identified an open pan-genome consisting of 19.9% core and 77.6% accessory genes, with cattle isolates phylogenetically clustering alongside human, environmental, and food-source isolates.

Cite This Study

Fahmy et al. (2026) studied this question.

synapsesocial.com/papers/6a97e28dc562ede874ec6bc9https://doi.org/10.1128/spectrum.01581-26
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