Protective effects of 1,8-cineole against potassium dichromate-induced nephrotoxicity in rats: Evaluation of oxidative stress, inflammatory, and apoptotic pathways

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1,8-cineole exerts protective effects against potassium dichromate-induced nephrotoxicity by mitigating oxidative stress and inflammation. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

Tansu Kuşat; Feyza Başak; Eyüp Altınöz; Yasemin Biçer

doi:10.29058/mjwbs.1911696

August 31, 2026Medical Journal of Western Black SeaOpen Access

Protective effects of 1,8-cineole against potassium dichromate-induced nephrotoxicity in rats: Evaluation of oxidative stress, inflammatory, and apoptotic pathways

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Key Points

To evaluate the protective effects of 1,8-cineole against potassium dichromate-induced renal toxicity and examine its influence on oxidative stress, inflammation, and apoptosis.
Randomized 40 male Wistar albino rats into five treatment groups (n=8 per group): control, vehicle, potassium dichromate (PD), 1,8-cineole (CN), and PD combined with CN.
Administered all treatments orally once daily for 28 consecutive days.
Measured renal oxidative stress markers (MDA, GSH, CAT, SOD), inflammatory cytokines (NF-κB, TNF-α), Bax apoptotic expression via immunohistochemistry, and histopathological changes.
Potassium dichromate exposure induced significant renal damage, marked by increased levels of MDA, NF-κB, and TNF-α alongside depleted GSH, SOD, and CAT activities.
Co-treatment with 1,8-cineole counteracted potassium dichromate-induced alterations, suppressing oxidative stress, inflammatory mediators, and renal tissue injury.

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Implication

Controlled animal study demonstrates that 1,8-cineole alleviates potassium dichromate-induced nephrotoxicity in rats, suggesting therapeutic potential against heavy metal kidney injury.

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Kuşat et al. (2026) studied this question.

synapsesocial.com/papers/6a97e29ec562ede874ec6d7c https://doi.org/10.29058/mjwbs.1911696

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Protective effects of 1,8-cineole against potassium dichromate-induced nephrotoxicity in rats: Evaluation of oxidative stress, inflammatory, and apoptotic pathways

Key Points

No abstract yet

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Implication

Discussion

Cite This Study

Protective effects of 1,8-cineole against potassium dichromate-induced nephrotoxicity in rats: Evaluation of oxidative stress, inflammatory, and apoptotic pathways

Key Points

No abstract yet

Ask about this paper

Implication

Discussion

Cite This Study

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