What does this research mean for the field?

1,8-cineole exerts protective effects against potassium dichromate-induced nephrotoxicity by mitigating oxidative stress and inflammation. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

What question did this study set out to answer?

To evaluate the protective effects of 1,8-cineole against potassium dichromate-induced renal toxicity and examine its influence on oxidative stress, inflammation, and apoptosis.

September 2, 2026Medical Journal of Western Black SeaOpen Access

Protective effects of 1,8-cineole against potassium dichromate-induced nephrotoxicity in rats: Evaluation of oxidative stress, inflammatory, and apoptotic pathways

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TKTansu Kuşat FBFeyza Başak EAEyüp Altınöz

Discussion

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Overview

Controlled animal study demonstrates that 1,8-cineole alleviates potassium dichromate-induced nephrotoxicity in rats, suggesting therapeutic potential against heavy metal kidney injury.

Key Points

To evaluate the protective effects of 1,8-cineole against potassium dichromate-induced renal toxicity and examine its influence on oxidative stress, inflammation, and apoptosis.
Randomized 40 male Wistar albino rats into five treatment groups (n=8 per group): control, vehicle, potassium dichromate (PD), 1,8-cineole (CN), and PD combined with CN.
Administered all treatments orally once daily for 28 consecutive days.
Measured renal oxidative stress markers (MDA, GSH, CAT, SOD), inflammatory cytokines (NF-κB, TNF-α), Bax apoptotic expression via immunohistochemistry, and histopathological changes.
Potassium dichromate exposure induced significant renal damage, marked by increased levels of MDA, NF-κB, and TNF-α alongside depleted GSH, SOD, and CAT activities.
Co-treatment with 1,8-cineole counteracted potassium dichromate-induced alterations, suppressing oxidative stress, inflammatory mediators, and renal tissue injury.

Cite This Study

Kuşat et al. (2026) studied this question.

synapsesocial.com/papers/6a97e29ec562ede874ec6d7c https://doi.org/10.29058/mjwbs.1911696

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September 2, 2026Medical Journal of Western Black SeaOpen Access

Protective effects of 1,8-cineole against potassium dichromate-induced nephrotoxicity in rats: Evaluation of oxidative stress, inflammatory, and apoptotic pathways

View Full Paper

Ask AI

Bookmark

Authors

TKTansu Kuşat FBFeyza Başak EAEyüp Altınöz

Discussion

Member takes

Overview

Controlled animal study demonstrates that 1,8-cineole alleviates potassium dichromate-induced nephrotoxicity in rats, suggesting therapeutic potential against heavy metal kidney injury.

Key Points

To evaluate the protective effects of 1,8-cineole against potassium dichromate-induced renal toxicity and examine its influence on oxidative stress, inflammation, and apoptosis.
Randomized 40 male Wistar albino rats into five treatment groups (n=8 per group): control, vehicle, potassium dichromate (PD), 1,8-cineole (CN), and PD combined with CN.
Administered all treatments orally once daily for 28 consecutive days.
Measured renal oxidative stress markers (MDA, GSH, CAT, SOD), inflammatory cytokines (NF-κB, TNF-α), Bax apoptotic expression via immunohistochemistry, and histopathological changes.
Potassium dichromate exposure induced significant renal damage, marked by increased levels of MDA, NF-κB, and TNF-α alongside depleted GSH, SOD, and CAT activities.
Co-treatment with 1,8-cineole counteracted potassium dichromate-induced alterations, suppressing oxidative stress, inflammatory mediators, and renal tissue injury.

Cite This Study

Kuşat et al. (2026) studied this question.

synapsesocial.com/papers/6a97e29ec562ede874ec6d7c https://doi.org/10.29058/mjwbs.1911696

View Full Paper

Ask AI

Bookmark