Accumulation of Ultrasmall Superparamagnetic Particles of Iron Oxide in Human Atherosclerotic Plaques

We read with interest the recent article by Kooi et al, 1 reporting their experience with ultrasmall superparamagnetic iron oxide (USPIO)-enhanced magnetic resonance (MR) imaging of carotid atheroma. This exploratory study holds promise for contrast-enhanced MR imaging of inflammatory lesions. We do express some reservations, however, regarding the authors' methodology, conclusions, and the quality of the MR images on which they base their findings.