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September 2, 2026Retina

Comparative Incidence of Cystoid Macular Edema after Secondary Intraocular Lens Placement Versus Routine and Complex Cataract Surgery

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Authors

CZCharles ZhangSESinan ErsanABAlexander S Bae

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Overview

Retrospective cohort study reveals higher cystoid macular edema incidence after secondary intraocular lens placement in adults, highlighting the need for increased postoperative vigilance.

Key Points

  • To compare the cumulative 90-day incidence of postoperative cystoid macular edema following secondary intraocular lens placement versus routine and complex cataract surgery.
  • Retrospective cohort study of adult patients within the TriNetX US Collaborative Network undergoing routine cataract surgery (N=506,095), complex cataract surgery (N=99,337), or secondary intraocular lens placement (N=12,644).
  • Conducted propensity score matching and multivariable Cox proportional hazards regression to evaluate 90-day cystoid macular edema risk and assess the impact of concurrent pars plana vitrectomy.
  • Postoperative cystoid macular edema incidence was 5.1% after secondary intraocular lens placement, significantly higher than routine cataract surgery (1.4%; RR 3.6; p<0.0001) and complex cataract surgery (2.0%; RR 2.5; p<0.0001).
  • Multivariable Cox proportional hazards modeling demonstrated an increased hazard of cystoid macular edema for secondary intraocular lens implantation compared to routine cataract surgery (HR 3.6; p<0.0001).
  • Concurrent pars plana vitrectomy during secondary intraocular lens placement increased cystoid macular edema risk to 7.1% versus 5.3% without vitrectomy (p<0.0001), while prophylactic nonsteroidal anti-inflammatory eyedrop use was lower in secondary cases (23% vs 32–34%; p<0.0001).

Cite This Study

Zhang et al. (2026) studied this question.

synapsesocial.com/papers/6a97e2d9c562ede874ec73ddhttps://doi.org/10.1097/iae.0000000000005003
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Cystoid Macular Edema Following Phacoemulsification and Posterior Chamber Intraocular Lens Surgery: An Aspect From the Past to the Present2025 · 1 citations
  2. 2FREQUENCY OF CYSTOID MACULAR EDEMA ON OPTICAL COHERENCE TOMOGRAPHY IN TWO DIFFERENT TYPES OF CATARACT SURGERY2024 · 1 citations
  3. 3Outcomes and Complications of Secondary Intraocular Lens Implantation: Insights From a Vitreoretinal Surgery Cohort2026
  4. 4Risk Factors for Development of Uveitis and Cystoid Macular Edema After Cataract Surgery2025 · 1 citations
  5. 5Incidence of Acute Endophthalmitis after Secondary Intraocular Lens Implantation: A Nationwide Cohort Study2024 · 1 citations