Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
September 2, 2026Synlett

Chromium-Catalyzed Reductive Alkenylation and Alkylation of Aryl Iodides

View Full Paper
Ask AI
Bookmark
Share

Authors

PPPan PanKJKangyuan JiNLNan Li

Discussion

Loading...

Member takes

Overview

Experimental study demonstrates chromium-catalyzed reductive alkenylation and alkylation of aryl iodides at room temperature, highlighting an inexpensive alternative to nickel and cobalt catalysts.

Key Points

  • Develop a mild, room-temperature cross-electrophile coupling protocol for the direct alkylation and alkenylation of aryl iodides using an earth-abundant catalyst.
  • Utilized inexpensive chromium trichloride (CrCl₃) as the catalyst for reductive cross-coupling.
  • Conducted reactions at ambient room temperature to synthesize C(sp2)–C(sp2) and C(sp2)–C(sp3) bonds across diverse aryl iodide substrates.
  • Enabled efficient construction of both C(sp2)–C(sp2) and C(sp2)–C(sp3) carbon frameworks under mild conditions.
  • Showed broad functional-group tolerance, effectively coupling challenging, sterically encumbered ortho-substituted arenes.
  • Displayed high chemoselectivity favoring cross-coupling products over homocoupled dimer byproducts.

Cite This Study

Pan et al. (2026) studied this question.

synapsesocial.com/papers/6a97e2eac562ede874ec749ahttps://doi.org/10.1055/a-2949-1923
View Full Paper
Ask AI
Bookmark
Share