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Experimental study demonstrates chromium-catalyzed reductive alkenylation and alkylation of aryl iodides at room temperature, highlighting an inexpensive alternative to nickel and cobalt catalysts.
A mild and efficient chromium-catalyzed cross-electrophile coupling method has been developed for the direct alkylation and alkenylation of aryl iodides. Using inexpensive CrCl₃ as the catalyst, this protocol enables the construction of C(sp2)–C(sp2) and C(sp2)–C(sp3) bonds at room temperature. The system exhibits broad functional-group tolerance, including ortho-substituted arenes, and displays excellent chemoselectivity for cross-coupling over homocoupling. This work provides a cost-effective chromium-based alternative to conventional nickel- or cobalt-catalyzed reductive cross-coupling strategies.
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Pan et al. (2026) studied this question.
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