Key result
Contrast medium first-pass MRI demonstrated highly significant changes in calf muscle signal dynamics during reactive hyperemia compared to the resting contralateral leg.
Why the study?
Does contrast medium first-pass MRI detect changes in skeletal muscle perfusion during reactive hyperemia compared to rest in healthy volunteers?
Observational (n=20)
Does contrast medium first-pass MRI detect changes in skeletal muscle perfusion during reactive hyperemia compared to rest in healthy volunteers?
First-pass MRI shows potential for visual detection of reduced tissue perfusion in skeletal muscle, though numerical assessment requires disentanglement of inflow and contrast effects.
First-pass MRI visualizes skeletal muscle perfusion changes in healthy volunteers; leaves open clinical translation pending validation in patients.
PURPOSE: To probe the potential and pitfalls of contrast medium first-pass skeletal muscle perfusion imaging under reproducible stress conditions. MATERIALS AND METHODS: Magnetic resonance (MR) signal dynamics in calf muscle and lower-leg arteries of 20 healthy volunteers were analyzed under postarterial occlusion reactive hyperemia and concurrent contrast medium first pass, using a saturation recovery spoiled gradient-echo type sequence without heartbeat synchronization. The signal vs. time curves were analyzed descriptively and by two-compartment deconvolution analysis. RESULTS: Highly significant changes in calf muscle signal dynamics in the hyperemic leg vs. those in the contralateral leg at rest were found in phenomenological and deconvolution analysis. Although a distortion of the arterial signal derived input function by inflow effects was found to cause large variations of the deconvolution results, the magnitude of the observed effects suggested a potential for immediate visual detection of areas with reduced tissue perfusion. CONCLUSION: The first-pass approach appeared promising for visual evaluation. However, a disentanglement of inflow and contrast medium-induced effects on arterial signal intensity was deemed a prerequisite for input function-based numerical assessment.
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Lutz et al. (2004) conducted an observational in Healthy volunteers (n=20). Contrast medium first-pass skeletal muscle perfusion imaging under reactive hyperemia vs. Contralateral leg at rest was evaluated on MR signal dynamics in calf muscle and lower-leg arteries. Contrast medium first-pass MRI demonstrated highly significant changes in calf muscle signal dynamics during reactive hyperemia compared to the resting contralateral leg.
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