Treatment of Polycythemia

Article1 August 1933TREATMENT OF POLYCYTHEMIATHE RETICULOCYTE RESPONSE TO VENESECTION, PHENYLHYDRAZIN AND RADIATION*ERNEST H. FALCONER, M.D., F.A.C.P.ERNEST H. FALCONER, M.D., F.A.C.P.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-7-2-172 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptVenesection was formerly frequently employed as a therapeutic measure in the treatment of polycythemia, but its results have not been systematically studied. It has usually been considered as a measure of expediency rather than one of real value in the treatment of this condition. One of the present common objections to its use is based on the premise that repeated bleeding stimulates the bone marrow excessively, tending to premature exhaustion.It was to test the validity of this premise, as applied to polycythemia vera, that this study was undertaken. The administration of phenylhydrazin hydrochloride by mouth, or radiation over spleen...Bibliography1. ALLENGIFFIN EVHZ: Experiments with phenylhydrazin. I. Studies in the blood. II. Studies on renal and hepatic function and erythropoiesis, ANN. INT. MED., 1928, i, 655, 677. Google Scholar2. GIFFINCONNER HZHM: The untoward effects of treatment by phenylhydrazine hydrochloride, Jr. Am. Med. Assoc., 1929, xcii, 1505-1507. CrossrefGoogle Scholar3. BRATLEYBURROUGHSHAMILTONKERN FGHHDMC: The effects of pyrodin poisoning on the blood and hemolytopoietic system, with especial reference to the formation of Heinz-Ehrlich bodies in vivo and vitro, Am. Jr. Med. Sci., 1931, clxxxii, 597-605. CrossrefGoogle Scholar4. LONG PH: Effect of phenylhydrazin derivatives in the treatment of polycythemia, Jr. Clin. Invest., 1926, ii, 315-328. CrossrefGoogle Scholar5. ALTNOWCAREY HOJB: A case of polycythemia vera treated with phenylhydrazin hydrochloride with special reference to changes in blood morphology, Jr. Lab. and Clin. Med., 1927, xii, 597-606. Google Scholar6. GEISBÖCK F: Die Bedeutung der Blutdruckmessung für die Praxis, Deutsch. Arch. f. klin. Med., 1905, lxxxiii, 363-409. Google Scholar7. MINOTMURPHYSTETSON GRWPRP: The response of the reticulocytes to liver therapy, particularly in pernicious anemia, Am. Jr. Med. Sci., 1928, clxxv, 581-599. CrossrefGoogle Scholar8. CUNNINGHAM TD: A method for the permanent staining of reticulated red cells, Arch. Int. Med., 1920, xxvi, 405-409. CrossrefGoogle Scholar9. HURWITZFALCONER SHEH: The value of roentgen-rays and benzene in the treatment of polycythemia vera, Jr. Am. Med. Assoc., 1918, lxx, 1143-1145. CrossrefGoogle Scholar10. PARKES FW: Polycythemica hypertonica; is polycythemia a somewhat favorable sign in high blood pressure cases?, Brit. Med. Jr., 1927, ii, 98. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: ERNEST H. FALCONER, M.D., F.A.C.P.Affiliations: San Francisco, California*Read before the American College of Physicians, Montreal, February 7, 1933.From the Department of Medicine, University of California Medical School, San Francisco. This research was made possible by a grant from the Christine Breon Fund Income. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byPhenylhydrazine haematotoxicityPolycythemia vera: myths, mechanisms, and managementTHE OPTIMAL MANAGEMENT OF POLYCYTHAEMIA VERADie Therapie der Polycythaemia rubra vera Vaquez-OslerDie Therapie der Polycythaemia rubra vera Vaquez-OslerBLOOD-CELL CYCLES IN POLYCYTHAEMIA VERATreatment of Polycythemia Vera with large Venesections and Plasma Transfusions.Die Erkrankungen des erythrocytären SystemsTHE THERAPEUTIC USE OF VENESECTION IN POLYCYTHEMIA*D. J. STEPHENS, M.D., NOLAN L. KALTREIDER, M.D. 1 August 1933Volume 7, Issue 2Page: 172-189KeywordsBone marrowHemorrhageMouthPhlebotomyPolycythemiaPolycythemia veraSpleen ePublished: 1 December 2008 Issue Published: 1 August 1933 PDF downloadLoading ...