Key result
A theoretical closed-loop control system using an IPFM/SDC controller was simulated to regulate a sodium nitroprusside blood-pressure plant.
This theoretical paper describes a closed-loop control system for real-time regulation of physiological parameters such as blood pressure using sodium nitroprusside.
This theoretical paper discusses the realization of a discrete, closed-loop control system which uses an integral pulse frequency modulated/Smith delay compensator (IPFM/SDC) controller to regulate an in vivo physiological parameter to the prescribed quantity in real time. The pharmacokinetic (PK) plant considered is the sodium nitroprusside (SNP) blood-pressure plant. The simulated plant is appropriately time-and amplitude-scaled using op-amps and RC active filter elements.
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Woodruff et al. (1987) studied this question. IPFM/SDC controller was evaluated. A theoretical closed-loop control system using an IPFM/SDC controller was simulated to regulate a sodium nitroprusside blood-pressure plant.
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