What is the clinical evidence from this study?

Study design: Review. Population: Hemostatic disorders. Intervention: Platelet dysfunction.

What question did this study set out to answer?

Examine the cellular and molecular mechanisms by which platelet dysfunction disrupts hemostasis and contributes to bleeding and thrombotic disorders.

March 19, 2025International Journal of Molecular SciencesOpen Access

The Role of Platelet Dysfunctions in the Pathogenesis of the Hemostatic-Coagulant System Imbalances

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Key result

Platelet dysfunction contributes to the disruption of hemostasis, leading to an increased risk of both thrombosis and bleeding across various cardiovascular, metabolic, and autoimmune diseases.

Why the study?

Platelet dysfunction plays a critical role in disorders affecting the hemostatic-coagulant system, motivating an exploration of how these dysfunctions disrupt hemostasis to increase risks of thrombosis and bleeding.

Design

Review

Authors

OBOana Viola BădulescuGrigore T. Popa University of Medicine and Pharmacy MCManuela CiocoiuGrigore T. Popa University of Medicine and Pharmacy MVMaria Cristina VladeanuGrigore T. Popa University of Medicine and Pharmacy

Discussion

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Implication

May guide dual-risk assessment in hemostatic disorders; leaves open targeted interventions pending prospective trials.

Key Points

Examine the cellular and molecular mechanisms by which platelet dysfunction disrupts hemostasis and contributes to bleeding and thrombotic disorders.
Narrative review synthesizing molecular pathways of platelet activation, aggregation, and secretion under pathological conditions such as cardiovascular, metabolic, and autoimmune disorders.
Evaluation of clinical links to deep vein thrombosis, stroke, and disseminated intravascular coagulation alongside current antiplatelet interventions.
Platelet dysfunction disrupts essential interactions with clotting factors, fibrinogen, and vascular endothelium, elevating risks of both thrombosis and hemorrhage.
Pathological defects in platelet activation, aggregation, and secretion directly drive acute vascular complications, including stroke and disseminated intravascular coagulation.
Antiplatelet medications and emerging targeted therapies provide viable clinical pathways to rebalance dysfunctional hemostatic-coagulant cascades.

PICO

Population

Hemostatic disorders

Exposure / Comparator

Platelet dysfunction

This review highlights the molecular and cellular mechanisms of platelet dysfunction and its clinical implications in hemostatic disorders, emphasizing the need for targeted therapeutic strategies.

Cite This Study

Bădulescu et al. (2025) conducted a review in Hemostatic disorders. Platelet dysfunction was evaluated. Platelet dysfunction contributes to the disruption of hemostasis, leading to an increased risk of both thrombosis and bleeding across various cardiovascular, metabolic, and autoimmune diseases.

synapsesocial.com/papers/6a97ec12b58c727d448bfd01 https://doi.org/10.3390/ijms26062756

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The Role of Platelet Dysfunctions in the Pathogenesis of the Hemostatic-Coagulant System Imbalances

Discussion

Member takes

Implication

Key Points

PICO

Cite This Study

The Role of Platelet Dysfunctions in the Pathogenesis of the Hemostatic-Coagulant System Imbalances

Discussion

Member takes

Implication

Key Points

PICO

Cite This Study

Also Consider

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