During the past few years there has been striking progress in the development of penicillin preparations that are slowly absorbed and whose therapeutic effect is thereby prolonged. The aim has been to obtain a preparation that will give effective and prolonged concentrations of penicillin in the blood serum with infrequent injections. This is particularly desirable in the case of ambulatory patients, such as those being treated for syphilis. The purpose of this study was, first, to compare the efficacy of the various penicillin preparations as they became available and, second, to evaluate the influence of kidney function and the relationship of dose to weight on the height and duration of penicillin levels in the blood serum. This study represents the first stage of an over-all evaluation of penicillin in the treatment of syphilis as part of our continuing syphilis research program. Although no criterion has been established for the effective
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A. Benson Cannon (1951) studied this question.