An immunoelectrophoretic study was undertaken on two types of antibody detectable in human coccidioidomycosis, early precipitins and later complement-fixing antibodies. By using concentrated precipitin sera and dilute coccidioidal antigen, arcs of precipitation were produced which appeared to correspond to the mobility of 19S β2 macro-globulin. Complement-fixing sera and cerebro-spinal fluids reacted with coccidioidal antigen to give precipitation arcs with the mobility of 7S γ2 globulin.
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Pappagianis et al. (1965) studied this question.