A novel chiral ionic liquid, compound 1, based on camphorsulfonic acid, was prepared. A catalytic amount of 1 readily promotes L‐proline‐catalyzed aldol reactions, with good chemoselectivity, both in H2O and in organic solvents. Further, the aldol reaction of cyclohexanone with 4‐nitrobenzaldehyde afforded 2‐[hydroxy(4‐nitrophenyl)methyl]cyclohexanone (6) in 98% yield with high enantioselectivity (94% ee) when large amounts of 1 (5 equiv.) were used as promoter.
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Zhou et al. (2008) studied this question.
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