Key result
Murine complement component 3 variants segregated in a Mendelian manner and showed linkage to H-2 with a recombination frequency of approximately 0.12.
Population
Inbred and pen-bred strains of mice (46 inbred strains, plus Swiss-Webster animals)
Design
Preclinical
Authors
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No immediate clinical impact; leaves open whether analogous C3-MHC linkage influences human disease.
Effect estimate: recombination frequency ≈ 0.12
The study demonstrates that the gene controlling electrophoretic variants of murine complement component 3 (C3) is linked to the H-2 major histocompatibility complex with a recombination frequency of about 12%.
Silva et al. (1978) studied Genetic variation in murine complement component 3. Genetic variation (S and F alleles) was evaluated on Segregation of C3 with H-2 (recombination frequency ≈ 0.12). Murine complement component 3 variants segregated in a Mendelian manner and showed linkage to H-2 with a recombination frequency of approximately 0.12.
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