Subtotal Adrenalectomy in Cushing's Syndrome

Case Reports1 January 1956SUBTOTAL ADRENALECTOMY IN CUSHING'S SYNDROMEHERBERT W. COONE, M.D., F.A.C.P., JAMES W. HUMPHREYS JR., M.D., M.S. (Surgery), F.A.C.S.HERBERT W. COONE, M.D., F.A.C.P.Search for more papers by this author, JAMES W. HUMPHREYS JR., M.D., M.S. (Surgery), F.A.C.S.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-44-1-188 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe most effective treatment to date for Cushing's syndrome is not pituitary irradiation but subtotal adrenalectomy. This procedure has been reported in the medical literature in approximately 100 cases. There have been relatively few reports on patients with long follow-up in whom adrenocorticotropic hormones (ACTH) and cortisone have been used as supportive measures. A well documented case of this type is reported in this paper. The remarkable reversal of such findings as obesity, hypertension, osteoporosis, 17-ketosteroid production and other stigmata of the syndrome is again noted. As in other cases reported, ACTH and cortisone were found to minimize or eliminate...Bibliography1. ClarkQuartonCobbBauer LDGCSW: Further observations on mental disturbances associated with cortisone and ACTH therapy, New England J. Med. 249: 178, 1953. CrossrefMedlineGoogle Scholar2. RitterhoffRothermickVon HaamHamwiMorton RNOEGJL: Basophilic adenoma of the pituitary (Cushing's disease), Ohio State M. J. 49: 2, 1953. Google Scholar3. SpragueKvalePriestley RGWFJT: Management of certain hyperfunctioning lesions of the adrenal cortex and medulla, J. A. M. A. 151: 629, 1953. MedlineGoogle Scholar4. JohnsonHarper MEFR: The surgical treatment of Cushing's syndrome, Arch. Surg. 66: 517, 1953. CrossrefGoogle Scholar5. RakerCope JWO: Our experience with 34 cases of Cushing's disease, Harvard M. Bull. 27: 28, 1953. Google Scholar6. 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To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: *Received for publication February 17, 1955.Presented in part at the Ohio Regional Meeting, American College of Physicians, Cleveland, Ohio, January 14, 1955.From the Endocrine Clinic of the Medical Service and the Surgical Service, 2750th USAF Hospital, Wright-Patterson Air Force Base, Dayton, Ohio. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited bySurgery of the Adrenal GlandADRENALECTOMY IN CUSHING'S SYNDROME MANAGEMENT AND METABOLIC ASPECTS 1 January 1956Volume 44, Issue 1Page: 188-198KeywordsAdrenalectomyAdrenocorticotropic hormoneCholesterolHospitalsHypertensionMedical servicesObesityOsteoporosisPathogenesis ePublished: 1 December 2008 Issue Published: 1 January 1956 PDF downloadLoading ...