The syntheses and thermal rearrangements and/or fragmentations of 1,1‐difluorospiropentane, 6, 1,1,4,4‐ and 1,1,2,2‐tetrafluorospiropentanes, 7 and 8, 1,1,2,2,4,4‐hexafluorospiropentane, 9, and perfluorospiropentane, 10, are described., Spiropentanes 6 and 7 undergo only rearrangement to 2,2‐difluoromethylene‐cyclobutane and 1‐(difluoromethylene)cyclobutane and to 2,2,4,4‐tetrafluoromethylenecyclobutane, respectively. Spiropentanes 8 and 9 rearrange and extrude CF2: competitively, while perfluorospiropentane extrudes CF2: exclusively. Activation parameters are presented for all processes and the mechanisms of these thermal processes are discussed in detail.
No takes yet. Share an insight, caveat, or question.
Dolbier et al. (1981) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: