BACKGROUND: Osteoporosis and osteopenia, prevalent metabolic bone disorders, increase fracture risk, particularly in postmenopausal women. Chronic inflammation may contribute to bone loss. The association between inflammatory indices and bone mineral density (BMD) was investigated. MATERIALS AND METHODS: A cross-sectional analysis involving 99 patients over the age of 40 at the Ilam Rheumatology Clinic (2019-2022) evaluated BMD using the Hologic Discovery Wi DXA and assessed blood indices with the Sysmex XN-1000. Statistical analyses, including T-tests, ANOVA, and Pearson's correlation, were conducted utilizing SPSS version 16, with significance set at RESULTS: Among 99 patients (78.8% female, mean age 55.8 ± 9.7 years), the neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) exhibited significant elevation in cases of osteoporosis (2.710 ± 0.610, CONCLUSION: Increased levels of NLR and PLR correlate with diminished BMD, suggesting their potential as cost-effective biomarkers for osteoporosis risk assessment. Monitoring these indices could enhance early diagnosis and prevention strategies in at-risk populations.
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Selleck et al. (1998) studied this question.