Synthesis of New Phospholipids Linked to Steroid‐Hormone Derivatives Designed for Two‐Dimensional Crystallization of Proteins

The synthesis of phospholipids 1n–3n, rationally designed for two‐dimensional crystallization of progesterone and estradiol receptors, is reported. The structure of these lipids provides them with essential properties such as fluidity and stability when spread into monolayers at the air/H2O interface, affinity for the protein to be crystallized, and accessibility of the ligand under the lipid monolayer.