Viral infection induces production of antiviral proteins called interferons by cells of the innate immune system. In a Perspective, [Williams and Sen][1] discuss new work ([ Sharma et al .][2]) that identifies two kinases, which activate the transcription factor IRF3 responsible for switching on interferon synthesis. In addition, the authors discuss another study ([ Foy et al .][3]) identifying a serine protease in hepatitis C virus that is able to switch off IRF3 activation and thus block interferon production. [1]: http://www.sciencemag.org/cgi/content/full/300/5622/1100 [2]: http://www.sciencemag.org/cgi/content/short/300/5622/1148 [3]: http://www.sciencemag.org/cgi/content/short/300/5622/1145
No takes yet. Share an insight, caveat, or question.
Williams et al. (2003) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:
More from Science