Key result
Antibodies serve as indispensable tools for target characterization and validation in CNS therapeutic discovery programs targeting voltage-gated K+ channels.
Antibodies provide powerful tools for target selection and validation in CNS therapeutic discovery programs targeting voltage-gated K+ channels.
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Antibodies may aid CNS channel target validation; leaves open clinical translation in therapeutic programs.
Target validation and selection are critical early steps in the drug discovery process as they trigger substantial activity and investment to identify potential drug candidates. Antibodies play a crucial role in target selection as they provide powerful tools to explore the distribution and subcellular location of candidate molecules and can also be used to explore function. For studies of ion channel targets, antibodies are indispensable as they allow for direct exploration of the subunit composition of channel complexes in native tissues using biochemical and anatomical methods. This perspective summarizes the application of antibodies to target characterization and validation within the context of a CNS therapeutic discovery program targeting voltagegated K + channels. We also discuss a strategy for the
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Rhodes et al. (2008) reported a review. Antibody-based target validation was evaluated. Antibodies serve as indispensable tools for target characterization and validation in CNS therapeutic discovery programs targeting voltage-gated K+ channels.
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