Key result
Intravenous phenylephrine decreased the rostral spread of spinal anesthesia to cold sensation compared with ephedrine during cesarean delivery (median dermatome T3 vs T1; P=0.001).
Why the study?
Does intravenous phenylephrine reduce rostral spread of spinal anesthesia in pregnant women undergoing cesarean delivery compared with ephedrine?
Population
60 pregnant women undergoing combined spinal-epidural anesthesia for cesarean delivery
Comparison
Intravenous infusion of phenylephrine to prevent… vs Intravenous infusion of ephedrine (3 mg/ml)
Design
RCT, randomized, double blind
Follow-up
20 minutes
Authors
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Clinicians should anticipate lower block height with phenylephrine in cesarean spinal anesthesia; extends evidence on vasopressor effects on anesthetic spread.
RCT (n=60)
double blind
randomized
Does intravenous phenylephrine reduce rostral spread of spinal anesthesia in pregnant women undergoing cesarean delivery compared with ephedrine?
p-value: p=0.001
Intravenous phenylephrine decreases the rostral spread of spinal anesthesia during cesarean delivery compared with ephedrine.
Cooper et al. (2004) conducted an RCT in cesarean delivery (n=60). phenylephrine vs. ephedrine 3 mg/ml was evaluated on upper dermatome blocked to cold sensation at 20 min (p=0.001). Intravenous phenylephrine decreased the rostral spread of spinal anesthesia to cold sensation compared with ephedrine during cesarean delivery (median dermatome T3 vs T1; P=0.001).
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