Cucurbituril (CB), a well‐known macrocyclic cavitand, has been used extensively to construct supramolecular aggregates. Based on host‐guest intertactions, an adamantanyl derivative guest molecule was designed and synthesized to prepare a supramolecular amphiphile with cucurbit[7]uril. In aqueous solution, the cucurbit[7]uril based supramolecular amphiphiles self‐assemble into well‐defined vesicles, and their disassembly can be achieved by addition of excess competitive agent 1‐adamantanamine hydrochloride. This vesicle functions as a new nanocapsule to encapsulate molecules within its hollow cavity. Through competitive disassembly of supramolecular amphiphiles, the vesicles behave as a novel drug delivery carrier.
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Li et al. (2012) studied this question.
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