Key result
Human multiple sclerosis and the EAE animal model share a bidirectional relationship, where clinical observations in patients actively inform laboratory research.
Key points are not available for this paper at this time.
Design
Review
Patient insights iteratively refine EAE models; leaves open whether this strengthens MS therapeutic translation.
Concepts of the pathogenesis of MS are based on evidence from the animal model, EAE. Yet, the relationship between human MS and EAE is far from being a one-way road: many paths lead from the bedside back to animals in the laboratory.
No takes yet. Share an insight, caveat, or question.
Reinhard Hohlfeld (2009) studied this question. Human multiple sclerosis and the EAE animal model share a bidirectional relationship, where clinical observations in patients actively inform laboratory research.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: