Key result
A 10% echinomycin and hydrophobic heparin double-coating stent significantly reduced the histopathologic area of stenosis to 30.9% compared to 61.4% with a bare metal stent in a porcine model.
Why the study?
Does echinomycin-hydrophobic heparin double-coating stent reduce neointimal proliferation in a porcine coronary in-stent restenosis model?
Does echinomycin-hydrophobic heparin double-coating stent reduce neointimal proliferation in a porcine coronary in-stent restenosis model?
Echinomycin-hydrophobic heparin double-coating stents effectively inhibit neointimal proliferation in a porcine model, though high concentrations may cause local vascular toxicity.
Stent thrombosis and in-stent restenosis are still major limitations of coronary stenting. Here, we report on a new type of drug-eluting stent (DES) aimed to prevent restenosis and thrombosis. The DES was prepared by coating a bare metal stent with echinomycin (an anti-proliferative drug) and hydrophobic heparin. The echinomycin-hydrophobic heparin double-coating stents were compared with control stents in a porcine coronary stent restenosis model. Stent overdilation injury (stent: artery＝1.1: 1.0) was compared in porcine coronary arteries between 4 groups: bare stent group (Group I, n=3), 1 % echinomycin-heparin coating stent group (Group II, n=3), 5 % echinomycin-heparin coating stent group (Group III, n=3), and 10% echinomycin-heparin coating stent group (Group IV, n=3). Follow-up quantitative coronary angiography was performed 4 weeks after the stents were inserted. The histopathologic assessments of the stented porcine coronary arteries were compared between the 4 groups. The neointimal areas of the stented arteries were 4.3±1.3 mm2 in Group I, 5.7±1.3 mm2 in Group II, 3.7±1.0 mm2 in Group III, and 2.7±1.1 mm2 in Group IV; the neointimal area was significantly larger in Group II than in the other groups (p＜0.001). The histopathologic areas of stenosis were 61.4±18.1 % in Group I, 79.8±24.0 % in Group II, 52.0±18.5 % in Group III, and 30.9±14.6 % in Group IV; the histopathologic area was significantly smaller in Group IV than
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Lim et al. (2009) studied Coronary in-stent restenosis (n=12). Echinomycin and hydrophobic heparin double-coating stent vs. Bare metal stent was evaluated on Histopathologic area of stenosis (p=<0.001). A 10% echinomycin and hydrophobic heparin double-coating stent significantly reduced the histopathologic area of stenosis to 30.9% compared to 61.4% with a bare metal stent in a porcine model.
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