Key result
A neurobehavioral test battery in rodents assesses autonomic, neuromuscular, sensory, and excitability functions to screen for neurotoxicological effects.
Rodent neurobehavioral battery enables standardized toxicity screening; leaves open translation to human cardiovascular risk assessment.
Neurobehavioral evaluations are an important component of screening for neurotoxicological effects. A neurobehavioral test battery is chosen to assess a variety of endpoints, including autonomic, neuromuscular, sensory, and excitability functions. Such a battery includes observation of gait and posture, reactivity and arousal, gait and postural characteristics, involuntary/abnormal motor movements, clinical signs and manipulation of neurological reflexes and reactions and neuromuscular activity and postural reactions. Finally, the battery includes assessment of sensory responses.
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Virginia C. Moser (1999) conducted a review in Neurotoxicological effects. Neurobehavioral test battery was evaluated on Autonomic, neuromuscular, sensory, and excitability functions. A neurobehavioral test battery in rodents assesses autonomic, neuromuscular, sensory, and excitability functions to screen for neurotoxicological effects.
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