N-Acetylcysteine (NAC) acts as a precursor for glutathione biosynthesis (1, 2), in addition to performing several other biological functions in mammals and bacteria (1, 5). As per our earlier studies (3, 4), glutathione is an important modulator of antibiotic activity in bacteria; consequently, it is of interest to study the effect of NAC on bacterial antibiotic susceptibility. It becomes even more important since NAC is supplied as a mucolytic agent in combination with antibiotics during treatment of lower respiratory tract infection (1). Here we report the effect of NAC on various antibiotics against different bacterial strains, including opportunistic respiratory pathogens like Klebsiella and Pseudomonas.
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Goswami et al. (2010) studied this question.
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