Previous studies of an allotransplanted hamster lymphoma showed that excision of the immunizing tumor may lead to a fall in existing concomitant tumor immunity, increased production of enhancing antibodies, and metastatic tumor dissemination. We studied some variables that may influence this sequence of events. After tumor inoculation, a limited period exists when the immune response may be affected by tumor removal. The length of the susceptible period depends on the size of the initial tumor dose—the larger the dose, the shorter the period. Reinoculation of 1 × 107 tumor cells at the site of tumor removal, immediately after excision, can prevent the loss of concomitant immunity. Thus there is a period in the immune response to some tumor allografts which depends on continued antigenic stimulation for its development. Once this response is established it is no longer, or at least less, antigen dependent.
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Gershon et al. (1971) studied this question.