Key result
Cytoskeleton motors, including myosin, kinesin, and cytoplasmic dynein, play fundamental roles in neuron polarization, extension, shape, and neurotransmission through various molecular mechanisms.
This review highlights the structural basis and functional mechanisms of cytoskeleton molecular motors in neuronal development and neurotransmission.
Cells make use of molecular motors to transport small molecules, macromolecules and cellular organelles to target region to execute biological functions, which is utmost important for polarized cells, such as neurons. In particular, cytoskeleton motors play fundamental roles in neuron polarization, extension, shape and neurotransmission. Cytoskeleton motors comprise of myosin, kinesin and cytoplasmic dynein. F-actin filaments act as myosin track, while kinesin and cytoplasmic dynein move on microtubules. Cytoskeleton motors work together to build a highly polarized and regulated system in neuronal cells via different molecular mechanisms and functional regulations. This review discusses the structures and working mechanisms of the cytoskeleton motors in neurons.
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Xiao et al. (2016) reported a review. Cytoskeleton molecular motors was evaluated. Cytoskeleton motors, including myosin, kinesin, and cytoplasmic dynein, play fundamental roles in neuron polarization, extension, shape, and neurotransmission through various molecular mechanisms.
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