From tumors involving the pineal gland, two distinct systems of symptoms and signs ensue, the neurologic and the metabolic. The neurologic manifestations arise from the encroachment of the neoplasm on the intracranial contents and are indications of changes in pressure, in placement and of destruction of tissue. Such changes are the consequence of pineal tumors at any age of the patient; but in pineal tumors appearing in prepuberal life a second group of changes arise, the metabolic. These metabolic alterations are referable to disturbance in the gland's secretory function. Apparently only in young males is this syndrome complete.1It consists of (1) early sexual development evidenced in the enlarged sex organs, pubic hair, general body hair, early changes in voice; (2) precocious mental development evidenced in the maturity of thought and speech, and (3) general body overgrowth to the extent that a child of 5 or 6 years may
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Carey P. McCord (1914) studied this question.