The release of fibrinolytic agents from human cornea was studied by culturing foetal corneal explants in the presence of a standard fibrin clot and measuring the fibrin degradation products formed in the culture medium. Cultures of cornea were found to invariably release a significant amount of fibrinolytic agents, probably fibrinolytic activators, since Tranexamic acid, an inhibitor of plasminogen activation into plasmin, completely blocked the dissolution of the clot in the culture system. The function of these fibrinolytic activators is presumably to keep the cornea free from fibrin deposits which may occur after injury or inflammation.
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Pandolfi et al. (1972) studied this question.
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