The expression of voltage-dependent calcium channel alpha 1 and alpha 2 subunit mRNAs is developmentally regulated during the differentiation of C2C12 myogenic cells.
Supports myogenic differentiation research; leaves open translation to human muscle physiology or channel function.
The voltage-dependent calcium channel (VDCC) in skeletal muscle probably plays a key role in transducing membrane charge movement to the calcium release channel. We report here that the expression of VDCC alpha 1 and alpha 2 mRNAs is developmentally regulated in differentiating C2C12 myogenic cells. The alpha 1 mRNA is not detectable in the myoblast form of C2C12 cells while its expression is induced 20-fold in differentiated myotubes. In contrast, the alpha 2 mRNA is weakly expressed in myoblasts but is also induced upon myogenic differentiation.
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Váradi et al. (1989) studied this question.
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