Key result
In patients with chronic kidney disease, serum D-dimer levels demonstrated a significant negative correlation with glomerular filtration rate (R = -0.2975, p = 0.0029).
Why the study?
Given the high sensitivity of D-dimer assessment when ruling out pulmonary embolism, the study investigated D-dimer levels in CKD patients based on their related GFR.
Cross-Sectional (n=98)
No
In patients with CKD, D-dimer levels are negatively correlated with GFR and positively correlated with age, suggesting a need for GFR-adjusted cut-offs to avoid false-positive VTE diagnoses.
May elevate false-positive VTE risk in low-GFR CKD; leaves open validation of GFR-adjusted D-dimer thresholds.
Background: Given the high sensitivity of the D-dimer assessment when ruling out pulmonary embolism, the present study was conducted to investigate the D-dimer levels in patients with CKD based on their related GFR. Methods: The present cross-sectional study included 98 patients with CKD who presented to the nephrology clinic of the Shahid Beheshti Hospital in Hamadan, Iran. The patients gave informed consent before enrollment. The data of each patient was recorded in the form of a checklist. The data analysis was performed using the SPSS software at a significance level of 0.05%. Results: There was found to be a negative correlation between GFR and D-dimer levels in the study participants. However, there was no evidence of thromboembolic events during the 1-year follow-up. Moreover, we found a direct relationship between patient age and the serum levels of the D-dimer, in that the D-dimer levels were higher in the participants who were older. Conclusion: We concluded that serum D-dimer level has a positive correlation with age, while it has a negative correlation with GFR in CKD patients. However, no evidence of thromboembolic events was found.
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Sheikh et al. (2021) conducted a cross-sectional in Chronic Kidney Disease (n=98). Decreased Glomerular Filtration Rate (GFR) vs. Higher GFR was evaluated on Correlation between GFR and D-dimer levels (R = -0.2975, p=0.0029). In patients with chronic kidney disease, serum D-dimer levels demonstrated a significant negative correlation with glomerular filtration rate (R = -0.2975, p = 0.0029).
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