Key result
Exercise training induces beneficial biochemical adaptations that protect vulnerable tissues from doxorubicin-induced cellular toxicity without compromising its therapeutic efficacy.
Why the study?
There is currently no standard of care practice to prevent doxorubicin-induced cellular toxicity to off-target organs, prompting interest in exercise to improve tolerance and reduce side effects.
Does regular physical activity reduce doxorubicin-induced cellular toxicity in cancer patients?
Does regular physical activity reduce doxorubicin-induced cellular toxicity in cancer patients?
Exercise is a promising non-pharmacological adjunct therapy to prevent or reduce doxorubicin-induced multi-organ toxicity, including cardiotoxicity.
Answers are grounded in this paper and cite their sources.
Exercise may mitigate doxorubicin toxicity in cancer patients; leaves open confirmation in randomized trials before practice change.
Doxorubicin is an anthracycline antibiotic used for the treatment of a wide range of cancers. But unfortunately, due to its accumulation within healthy tissues, DOX treatment results in side effects of cellular toxicity. DOX-induced cellular toxicity occurs as a result of increasing oxidative damage, resulting in apoptosis and cell death. There is currently no standard of care practice to prevent DOX-induced toxicity to off-target organs. Therefore, scientists and researchers are seeking to further development and improvement of the treatment for this deadly disease. Meanwhile, the combination of exercise and chemotherapy is a promising method for efficiency and tolerance and reduction of side effects and drug resistance. Physical activities stimulate numerous beneficial biochemical adaptations resulting in a healthy phenotype in vulnerable tissues, without affecting the antineoplastic properties of DOX. Therefore, determining the appropriate exercise regimen is important to prescribe those cancer patients receiving DOX therapy because the patient's physical and medical conditions must be considered. The present review study investigates the cytotoxic effects of DOX on the heart, liver, kidney and lungs, discussing the benefits of the role of regular physical activity and potential mechanisms dealing with the positive effects of exercise on each system.
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Chashemi et al. (2020) conducted a review in Doxorubicin-induced cellular toxicity. Exercise was evaluated. Exercise training induces beneficial biochemical adaptations that protect vulnerable tissues from doxorubicin-induced cellular toxicity without compromising its therapeutic efficacy.
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