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A helical home for copper: A sequential, in situ desilylation/dimerization/decomplexation protocol has been used to generate helical enyne-bridged heterocycles in a copper(I) templated synthesis. Variable temperature 13C NMR analysis of the copper complex (see calculated structure) indicated the barrier to helical isomerization was 13.6 kcal mol−1, an increase of about 4 kcal mol−1 relative to the uncomplexed cyclophane.
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Heuft et al. (2002) studied this question.
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