The Production of Ulcer of the Stomach by Injection of Streptococci

Hemorrhages, superficial erosions and definite ulceration of the mucous membrane of the stomach and duodenum occur not infrequently during severe infections in man and in experimentally infected or otherwise severely intoxicated animals. In some of these instances there can be no question but that infection in some instances plays a role in the etiology of ulcer.1Ulcer also has been produced experimentally by injecting bacteria into the gastric artery. The association of mouth and tonsillar infections with ulcer of the stomach has been emphasized. It is said that ulcer of the stomach is more common in regions in which throat infections are particularly prevalent. Clinicians have observed aggravation of symptoms in ulcer of the stomach or duodenum following sore throat. Experimental proof, however, showing that certain bacteria may have a special affinity for the stomach mucous membrane, producing a localized infection, and hence may play a role in the