Successful and steady response to a combination of lamotrigine and quetiapine of an extremely refractory bipolar I patient previously published as a case report: a seven years follow-up of the case report

Materials and methods During the 6 years that followed the patient manifested her first manic episode while for the rest of the time she was continuously depressed and attempted suicide three times. She received ECT without any benefit. She presented to us again after her last attempt. The diagnosis changed to Bipolar I disorder, current episode depressive. She was put on quetiapine 1500 mg, lamotrigine 300 mg and topiramate 50 mg daily. For the next 7 months the patient was normothymic with no residual symptoms.